896 research outputs found
When Untapped Talent Meets Employer Need: The Boston Foundation's Allied Health Strategy
Offers a three-year evaluation of an educational pipeline created in partnership with three hospitals to help low-income workers enter urgently needed healthcare occupations in terms of workers assisted, workforce development capacity, and collaboration
Fostering Resident Voice and Influence: The Making Connections Experience with Resident Engagement and Leadership
Resident engagement is often noted as a key element in neighborhood transformation and community change efforts, yet very little literature exists that explains and captures how resident engagement actually happens and what it takes to achieve lasting resident engagement capacity and success. As one step toward expanding the information available, this report presents insights gained by the Annie E. Casey Foundation after more than a decade of working with residents to achieve better results during the Making Connections initiative, Casey's signature community change effort of the 2000s. The report describes the various activities in which residents were engaged during Making Connections, the sequence and timing of those activities and some of the impact and community improvements that were achieved as a result. Through a focus on the Making Connections experience, the report highlights effective resident engagement strategies and assesses the factors that can inhibit or enhance their effectiveness
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Genetic Associations of Alzheimer’s Disease and Mild Cognitive Impairment
Over 6 million people are estimated to have been living with Alzheimer’s Disease (AD) in 2020, with another 12 million living with Mild Cognitive Impairment (MCI). Research has been conducted to evaluate genetic links to AD, but more research is needed on the subject. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) has been conducting a longitudinal study of AD and MCI since 2004 and offering their data to research teams around the world. Diagnostic and demographic data was collected from participants, as well as data regarding single nucleotide polymorphisms (SNPs). SNP data was transformed to a binary format regarding whether the SNP contained the alternative allele for that particular SNP. We performed cross-validation to determine the ideal alpha and lambda values to use in elastic net regularization, which called for LASSO regression, in order to perform feature selection on the SNPs and other predictors, which were systolic and diastolic blood pressure, age, gender, years of education, race, marital status, and handedness. The LASSO regression reduced the number of SNPs from 55,106 to 13 and removed all non-SNP predictors except years of education and marital status.
We used simple logistic regression to assess the relationship between variations in the significant SNPs (as well as years of education and marital status) and diagnosis of AD/MCI, utilizing a separate LASSO regression with conditional selective inference to more accurately calculate the significance of the variables. The adjusted odds ratios for the SNPs are 1.59 (95% CI 1.23, 2.05), 2.37 (95% CI 1.81, 3.12), 0.71 (95% CI 0.54, 0.93), 1.59 (95% CI 1.21, 2.09), 0.55 (95% CI 0.38, 0.79), 2.03 (95% CI 1.27, 3.23), 0.31 (95% CI 0.18, 0.50), 0.43 (95% CI 0.30, 0.60), 0.69 (95% CI 0.53, 0.89), 1.95 (95% CI 1.46, 2.60), 1.89 (95% CI 1.22, 2.90), 1.47 (95% CI 1.13, 1.90), and 0.52 (95% CI 0.37, 0.72) for SNPs rs11086694, rs2075650, rs2094277, rs2261682, rs31887, rs4745514, rs4816158, rs4826619, rs6640551, rs6809370, rs7312407, rs919751, and rs9857853, respectively. The SNPs are located in genes that have clinical significance and may be associated with various diseases that affect cognitive performance. The results propose that the alternative alleles for seven SNPs are associated with an increased risk of Alzheimer’s Disease/Mild Cognitive Impairment diagnosis while six SNPs are associated with a decreased risk of diagnosis. This research may have clinical implications and should be further studied
Local Voices: On-the-Ground Perspectives on Driving Community Change in the Making Connections Sites
This report describes, from the perspective of local stakeholders, the experience of several sites involved in Making Connections-- the Foundation's signature community change initiative of the 2000s -- in developing and enhancing the core capacities essential for articulating and pursuing a local community change agenda. The report describes the conditions in the communities when Making Connections began; the core capacities built during the decade-long initiative; the factors that contributed to capacity building; the evidence of improved outcomes for children, families and neighborhoods resulting from the enhanced change capacities; the continuing challenges of sustaining those capacities; and key takeaways from the experience
Changing Systems Is Like Moving a Mountain ... and Other Insights From Successful Workforce Leaders
Offers reflections on system-change leadership in the workforce development field from thirteen leaders involved in Casey's Jobs Initiative, including key leadership skills, motivation, challenges, and strategies. Suggests ways to support new leaders
Cops, consultants, and technology : an examination of innovation in the Boston Police Department : 1962-1974
Thesis. 1975. M.C.P.--Massachusetts Institute of Technology. Dept. of Urban Studies and Planning.Microfiche copy available in Archives and Rotch.Bibliography: leaves 209-213.by Scott M. Hebert.M.C.P
Prospectus, December 8, 1982
PHASE IV CONSTRUCTION BEGUN; News Digest; Winners announced!; Team appreciates coaching; Final Exam Schedule -- Fall \u2782; Signs should be read; Hard work noted; Votes appreciated; Flour and bfan salad?; \u27People\u27 winners; \u27General Subject\u27 winners; Honorable Mention; Pro-file; ISO members pleased with fair; Classified; Accounting offers Yaxley scholarship; Easton reaching full bloom as artist; Dream comes true; Use that useless knowledge, win cash!; T-Bird third out; Idol goes solo; Choose movies!; Students unconcerned about apat; Parkland club noteshttps://spark.parkland.edu/prospectus_1982/1001/thumbnail.jp
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